Emmanouil Mathioulakis

National Center of Research

Title: Exercise as Medicine: Molecular Mechanisms of Atherosclerotic Plaque Stabilization

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Biography

Abstract

Abstract
Physical exercise is universally recognized as a cornerstone in cardiovascular medicine. However, the precise molecular pathways through which exercise modulates arterial wall biology remain a major focus. As a representative of the "Exercise is Medicine" National Research Center, this presentation explores how exercise-induced mechanical forces, such as endothelial shear stress, trigger specific molecular cascades that promote plaque stability. Specifically, we will analyze how regular exercise inhibits the NF-kB pathway, thereby downregulating critical endothelial adhesion molecules including Selectins, ICAM-1, and VCAM-1. Furthermore, we will discuss the clinical timing of exercise prescription, highlighting the distinct roles of aerobic continuous training for acute plaque stabilization and long-term anaerobic training for vascular conditioning once plaque stability is formed.

Abstract should give clear indication of the objectives, scope, results, methods used, and conclusion of your work. One figure and one table can be included in your results and discussions.

Keywords

Atherosclerotic plaque stability; Endothelial shear stress; NF-kB; Cell adhesion molecules; Exercise is Medicine.

Recent Publications: Minimum 3 publications to be included (Not mandatory)

Emmanouil Mathioulakis is a Clinical Exercise Cardiac Physiologist, Sports Medicine Specialist and a regular member of the National Center of Research "Exercise is Medicine" at the School of Medicine. He has extensive teaching experience in colleges and higher education institutes.